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If this medication is given right into a muscle or under the skin, it's important to vary The placement in the injection web page with Each individual dose in order to avoid problem areas under the skin.
When discontinuing therapy with hydromorphone hydrochloride injection or tablets within a individual who has become receiving the medication often and may be bodily dependent, it is actually sensible to slowly decrease the dose by 25% to fifty% each individual two to 4 times. This tapering approach needs to be performed while closely checking the affected individual for just about any indications of withdrawal indicators.
Watch sufferers for signs of respiratory depression Which may be bigger than otherwise expected and decrease the dosage of DILAUDID INJECTION and/or the muscle relaxant as required.
Inform individuals of the risk of life-threatening respiratory depression, which includes information that the chance is greatest when commencing DILAUDID INJECTION or when the dosage is increased, and that it could arise even at suggested dosages.
Naltrexone and nalmefene are opioid receptor antagonists which can bring about withdrawal symptoms when used with hydromorphone and diminish its analgesic effect.
Opioid use increases the potential risk of CSA in a very dose-dependent trend. In individuals who present with CSA, consider reducing the opioid dosage utilizing best tactics for opioid taper [see DOSAGE AND ADMINISTRATION].
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Hydromorphone causes a reduction in motility related with an increase in smooth muscle tone in the antrum of the stomach and duodenum. Digestion of food while in the little intestine is delayed and propulsive contractions are decreased.
Additionally, Dilaudid is often abused for its sedating and euphoric effects. Abuse with the drug can be dangerous and potentially lethal. Because it makes pleasurable thoughts with Each individual dose, temptation to take A lot more of the drug trails at the rear of.
[12] Owing to your chance profile, the prescription and administration on the drug demand meticulous interest, along with a comprehensive understanding of its potential adverse effects and interactions.
This is normal which is nothing to worry about. Exalgo® extended-release tablets works in different ways than hydromorphone tablets, even at the same dose (variety of milligrams). Do not switch from the extended-release tablets to the fast-release tablets Except your medical professional informs dilaudid by iv you to. Be careful not to handle crushed or broken tablets. When you've got Make contact with with damaged or crushed tablets or spilled oral liquid, wash your skin or perhaps the affected locations with soap and drinking water without delay.
Suddenly stopping this medication may cause withdrawal, particularly if you might have used it for the long time or in high doses. To prevent withdrawal, your health care provider could lower your dose slowly but surely.
Taking an opioid medicine for many time during pregnancy can cause a withdrawal syndrome in the infant when the baby is born. This may be life-threatening if not treated.